OBJECTIVE: The outbreak of COVID-19 resulted mainly in respiratory disease; however, apart from that, the infection was presented with random systemic thromboembolic events. This study aimed to measure the serum concentration of antiphospholipid antibodies (IgM/IgG) in post-COVID and vaccinated individuals. Previous research resulted in the absence of IgG antibodies in COVID-19 patients.

PATIENTS AND METHODS: This quantitative study involved 132 participants (93 female cases - 70.5%, and 39 male cases - 29.5%). The age distribution of the participants was between 17 and 55 years. Serum antiphospholipid concentrations were measured by enzyme-linked immunoassay (ELISA) SARS-CoV-2 nucleocapsid protein.

RESULTS: There was no significant elevation of IgG antibodies either in post-COVID or in vaccinated individuals. However, the elevation of IgM was more significant.

CONCLUSIONS: Low serum concentrations of IgM and IgG antiphospholipid antibodies in COVID-19 patients support the existing literature that antiphospholipid antibody elevation is only transient, depending on the severity of the infection.