Chronic hepatitis C virus (HCV) infection is a major health problem worldwide: 130-150 million people are infected, with a percentage between 0.05% and 5% of pediatric cases. Up to now, the leading cause of infection in childhood is the vertical transmission, and no effective methods to prevent perinatal transmission are still available. This case report presents the successfully avoidance of a vertical infection by the treatment of HCV infected adolescent. The girl was treated with pegylated interferon and ribavirine and, after six months the end of the therapy, she discovered to be pregnant. The child was born after nine months by vaginal delivery, and he was breastfed up to 10 months of age. The screening of HCV antibodies at 12th month of age was negative, so the vertical transmission of HCV infection was excluded. Despite current EASL recommendations and NASPGAHN guidelines, there is still uncertainty about the timing of treatment initiation and no mention on the treatment of HCV infected female adolescents in childbearing age. Here we would invite to consider that the therapeutic intervention in adolescents could lead to a significant decrease in the HCV pediatric incidence, reducing either the sexual and the vertical transmission.