Hodgkin lymphoma (HL) in patients with HIV/AIDS is a challenging task because of the lack of established treatment and the need of meticulous attention to drug-drug interactions between highly active antiretroviral agents (HAART) and standard multi-agent chemotherapy. We report a case of recurrent HL in a patient, affected by HIV/AIDS and HCV-infection. The complex therapeutic management has been described; integrase inhibitors have shown a favorable interaction profile, allowing the completion of the chemotherapy regimen.