Hypersensitivity reactions to antiretroviral drugs, and especially dolutegravir, can happen seldomly. Though they are rare, it is of utmost importance to early identify signs and symptoms characterizing a hypersensitivity reaction in a patient with no known allergy or predisposition.

A 41-year-old female patient switched to a dolutegravir/abacavir/lamivudine regimen because of osteoporosis. This regimen was chosen because it has a low toxicity on the bone. Hypersensitivity reaction was not promptly recognized because of a negative HLA-B*5701 test. We present this case and a brief review of relevant similar cases in literature.