COVID-19 wreaked havoc and people's health was greatly threatened.  The front-line medical staff do their best to battle with epidemic and encounter great psychological pressure. It is imperative to pay attention to their mental health and analyze the causes of their psychological stress. Moreover, effective measures should be taken for psychological protection and guidance. In this paper, we summarize the psychological pressure of the front-line medical staff and its causes, as well as the measures taken in China. These measures provide an important reference for other countries to further do a good job in epidemic prevention and control and strive to eradicate the pandemic as soon as possible.