Coronavirus Disease 2019 (COVID-19) outbreak became a pandemic and has not even left the South Asian Association Regional Cooperation (SAARC) regions, consisting of Pakistan, Afghanistan, Bangladesh, India, Sri Lanka, Nepal, Maldives, and Bhutan. India has the worst condition with the highest number of confirmed cases in Asia and the second highest number of cases in the world. In the number of deaths, India stands on the 3rd rank in the world and first in SAARC countries. The only effective way to reduce the spread of COVID-19 is to limit human-to-human transmission by implementing lockdowns and curfews. However, the South Asian countries are now suffering from the second wave of COVID-19, in which the death rate is higher than the previous one. The COVID-19 vaccine has been developed by many countries and India is the only South Asian country that develops its own vaccine and also dispatches the doses of vaccines to other countries. Due to the densely populated region, South Asia is much vulnerable to COVID-19 rise. Protecting populations of vulnerable regions and promoting equality should be the priority of every country.