Photobacterium damselae subsp. damselae is commonly associated with infections in a variety of marine animals and rarely in humans. The authors report the first occurrence in Italy of an infection in a 44-year-old man caused by Photobacterium damselae on a pre-existing wound on the posterior face of the leg, acquired after diving in the coastal area of Platamona in Sardinia during the summer period. Besides the clinical case, we present the microbiological investigations and a systematic review of literature.