Infectious and noninfectious causes are involved in the etiology of acute pericarditis. However, the most common reported causes are virus infections. A 23-year-old female patient presented with complaints of fever, respiratory distress, and chest pain. Pericardial effusion was detected on transthoracic echocardiography. Anti-EBV VCA IgM test result was positive, and she was diagnosed with pericarditis due to Epstein-Barr virus (EBV) infection. She responded well to nonsteroidal anti-inflammatory therapy and clinically recovered completely. We present this rare case to highlight and investigate the cases of those infected with EBV infection with a multidisciplinary approach to avoid cardiac complications.